Tumor Necrosis Factor (TNF) Inhibitors

This Brief reviews the structure, function, and mechanisms of action found among the tumor necrosis factor (TNF) inhibitors. Given the significant difference among these agents, therapeutic interchange may be inappropriate. TNF inhibitors represent distinct biologic entities that perform diverse functional activities.


  • Discussion of the structure and binding profiles of the TNF inhibitors
  • Overview of activities at the points of impact
  • Review of the functional attributes of TNF inhibitors