The Disease Management Association of America (which now calls itself DMAA: The Care Continuum Alliance) has issued the second volume of the "Outcomes Guidelines Report." The original report sought to develop the correct way to calculate the return on investment of disease management programs. Volume 2 updates the previous version by adding new clinical measures, building on measuring financial outcomes in disease management and population health programs, providing a wellness program model, and focusing more on small populations. In particular, key clinical outcomes measures were developed jointly by DMAA and the National Committee for Quality Assurance (NCQA).